11.

Hemolysates were used to determine the activity of an enzyme found in red blood cells. The activity of a mutant form was compared to that of the normal enzyme. The Km of the mutant form was found to be the same as that of the normal enzyme, but the activity (per mg lysate) of the mutant form was 10% of the activity found in normal lysate. Which statement is consistent with these observations?

• a. The affinity of the mutant enzyme is 10 times higher than that of the normal enzyme.
• b. The affinity of the mutant enzyme is 10 times lower than that of the normal enzyme.
• c. The mutation decreases the stability of the enzyme in the red blood cell and has caused inactivation.
• d. The rate of synthesis of the mutant enzyme by red blood cells is 10% that of the normal enzyme.
• e. The rate of synthesis of the mutant enzyme by red blood cells is 10 times higher than the normal enzyme.