39.

In the small group discussion papers, one of the two defects responsible for extreme insulin resistance in the patient leprechaun/Ark-1 was

• a. a missense mutation in the alpha-subunit of the insulin receptor gene.
• b. a missense mutation in the hexose transporter gene.
• c. a deletion mutation in the tyrosine kinase domain of the insulin receptor gene.
• d. a nonsense mutation at the processing site (Arg-Lys-Arg-Arg) of the insulin receptor gene.